1257547-40-2
1257547-40-2 structure
- Name: PI3K-IN-37
- Chemical Name: PI3K-IN-37
- CAS Number: 1257547-40-2
- Molecular Formula: C25H26N6O2
- Molecular Weight: 442.51
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2022-09-07 20:04:32
- Modify Date: 2024-09-03 14:43:40
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PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1].
| Name | PI3K-IN-37 |
|---|
| Description | PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
PI3Kα:6 nM (IC50) PI3Kβ:8 nM (IC50) PI3Kδ:4 nM (IC50) mTOR:4 nM (IC50) |
| In Vitro | PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1]. PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1]. Cell Viability Assay[1] Cell Line: Rat1 cells Concentration: 0.005-10 μM Incubation Time: 30 min Result: Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of <5 nM, 8 nM, and 18 nM, respectively. Cell Viability Assay[1] Cell Line: TSC1-/- MEF cells Concentration: 0.005-1 μM Incubation Time: 60 min Result: Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM). |
| References |
[1]. FURET Pascal, et al. 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES. WO2010139731A1. |
| Molecular Formula | C25H26N6O2 |
|---|---|
| Molecular Weight | 442.51 |