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1637749-78-0

1637749-78-0 structure

1637749-78-0 structure

Name: RSK2-IN-2
Chemical Name: RSK2-IN-2
CAS Number: 1637749-78-0
Molecular Formula: C₁₆H₁₁N₅O
Molecular Weight: 289.29
Catalog: Signaling Pathways MAPK/ERK Pathway Ribosomal S6 Kinase (RSK)
Create Date: 2022-08-31 18:26:06
Modify Date: 2025-09-30 16:58:29
RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 (RSK2) kinase. RSK2-IN-2 is also described to inhibit MSK1, MSK2 and RSK3[1].

Name	RSK2-IN-2

Description	RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 (RSK2) kinase. RSK2-IN-2 is also described to inhibit MSK1, MSK2 and RSK3[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)
Target	RSK2 RSK3 MSK1 MSK2
In Vitro	RSK2-IN-2 (Compound 25) shows strong activity with ERK2-MSK1 cascade pIC50 of 9.6[1].
References	[1]. Hall A, et al. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. ACS Med Chem Lett. 2022 Jun 25;13(7):1099-1108.

Molecular Formula	C₁₆H₁₁N₅O
Molecular Weight	289.29

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