2687970-96-1
2687970-96-1 structure
- Name: TDI-011536
- Chemical Name: TDI-011536
- CAS Number: 2687970-96-1
- Molecular Formula: C19H16N4O2S
- Molecular Weight: 364.42
- Catalog: Signaling Pathways Stem Cell/Wnt YAP
- Create Date: 2022-09-04 10:24:53
- Modify Date: 2024-02-02 18:50:21
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TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].
| Name | TDI-011536 |
|---|
| Description | TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. |
|---|---|
| Related Catalog | |
| Target |
Lats kinase[1]. |
| In Vitro | TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of Müller glia in human retinal organoids[1]. Cell Proliferation Assay[1] Cell Line: human retinal organoids Concentration: 3 µM Incubation Time: 24 h, 5 days Result: Supressed Yap phosphorylation and promoted Müller glia proliferation. |
| In Vivo | TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1]. TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1]. Animal Model: Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1]. Dosage: 200 mg/kg Administration: Intraperitoneal injections; once. Result: Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day. Animal Model: Male 8-week-old mice (cryolesion model)[1]. Dosage: 100 mg/kg Administration: Intraperitoneal injections; once daily for 2 or 3 days. Result: Promoted cardiomyocytes proliferation. |
| References |
| Molecular Formula | C19H16N4O2S |
|---|---|
| Molecular Weight | 364.42 |