2560590-49-8

2560590-49-8 structure

Name: Topoisomerase II inhibitor 4
Chemical Name: Topoisomerase II inhibitor 4
CAS Number: 2560590-49-8
Molecular Formula: C₂₅H₂₅N₅O₄
Molecular Weight: 459.50
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-09-19 09:11:44
Modify Date: 2025-08-26 19:32:39
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].

Name	Topoisomerase II inhibitor 4

Description	Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II
In Vitro	Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50 values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1]. Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2]. Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2]. Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well [2]. Cell Migration Assay [2] Cell Line: HCT116, and WI-38 cells Concentration: 0.4, 0.6, 0.8, 1.0, 1.2 μM Incubation Time: 0, 12, 24, 48 hours Result: Resulted migration inhibition in HCT116 and SW480 cells. Cell Viability Assay[2] Cell Line: HCT116, and WI-38 cells Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM Incubation Time: 72 hours Result: Exerted anti-proliferative effect in a dose-dependent manner.
References	[1]. Li ZY, et al. Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors. Bioorg Chem. 2022 Feb. 119:105543. [2]. Chen JN, et al. E17 exerts anti-tumor activity through inhibiting topo II-mediated chromosomes condensation in CRC cells. Biochem Biophys Res Commun. 2019 May 28. 513(2):313-318.

Molecular Formula	C₂₅H₂₅N₅O₄
Molecular Weight	459.50

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