Topoisomerase II inhibitor 4

Modify Date: 2025-08-26 19:32:39

Topoisomerase II inhibitor 4 structure	Common Name	Topoisomerase II inhibitor 4
	CAS Number	2560590-49-8	Molecular Weight	459.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₅N₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase II inhibitor 4

Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].

Name	Topoisomerase II inhibitor 4

Description	Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II
In Vitro	Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50 values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1]. Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2]. Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2]. Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well [2]. Cell Migration Assay [2] Cell Line: HCT116, and WI-38 cells Concentration: 0.4, 0.6, 0.8, 1.0, 1.2 μM Incubation Time: 0, 12, 24, 48 hours Result: Resulted migration inhibition in HCT116 and SW480 cells. Cell Viability Assay[2] Cell Line: HCT116, and WI-38 cells Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM Incubation Time: 72 hours Result: Exerted anti-proliferative effect in a dose-dependent manner.
References	[1]. Li ZY, et al. Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors. Bioorg Chem. 2022 Feb. 119:105543. [2]. Chen JN, et al. E17 exerts anti-tumor activity through inhibiting topo II-mediated chromosomes condensation in CRC cells. Biochem Biophys Res Commun. 2019 May 28. 513(2):313-318.

Molecular Formula	C₂₅H₂₅N₅O₄
Molecular Weight	459.50

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Topoisomerase II inhibitor 4

Use of Topoisomerase II inhibitor 4

Names

Topoisomerase II inhibitor 4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.