1950635-36-5
1950635-36-5 structure
- Name: Thalidomide-4-O-CH2-COO(t-Bu)
- Chemical Name: tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate
- CAS Number: 1950635-36-5
- Molecular Formula: C19H20N2O7
- Molecular Weight: 388.37
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2022-09-25 16:00:37
- Modify Date: 2025-08-21 11:25:31
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Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
| Name | tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate |
|---|---|
| Synonyms | MFCD32643096 |
| Description | Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules. |
|---|---|
| Related Catalog |
| Molecular Formula | C19H20N2O7 |
|---|---|
| Molecular Weight | 388.37 |