Thalidomide-4-O-CH2-COO(t-Bu)

Modify Date: 2024-08-13 13:54:58

Thalidomide-4-O-CH2-COO(t-Bu) structure	Common Name	Thalidomide-4-O-CH2-COO(t-Bu)
	CAS Number	1950635-36-5	Molecular Weight	388.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₀N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-4-O-CH2-COO(t-Bu)

Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.

Name	tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate
Synonym	More Synonyms

Description	Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Molecular Formula	C₁₉H₂₀N₂O₇
Molecular Weight	388.37

MFCD32643096

Thalidomide-4-O-CH2-COO(t-Bu)

Use of Thalidomide-4-O-CH2-COO(t-Bu)

Names

Thalidomide-4-O-CH2-COO(t-Bu) Biological Activity

Chemical & Physical Properties

Synonyms