1628110-84-8

1628110-84-8 structure

Name: Penconazole-d7
Chemical Name: Penconazole-d7
CAS Number: 1628110-84-8
Molecular Formula: C₁₃H₈D₇CL₂N₃
Molecular Weight: 291.23
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2022-11-11 14:01:10
Modify Date: 2023-01-18 16:34:55
Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

Name	Penconazole-d7
Synonyms	(±)-Penconazole-d7 CGA 71818-d7 Ofir-d7 Omnex-d7 Topas-d7

Description	Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Neuronal Signaling >> AChE
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8. [3]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 201736(8):854-866.