Penconazole-d7

Modify Date: 2023-01-18 16:34:55

Penconazole-d7 Structure
Penconazole-d7 structure
Common Name Penconazole-d7
CAS Number 1628110-84-8 Molecular Weight 291.23
Density 1.3±0.1 g/cm3 Boiling Point 415.3±55.0 °C at 760 mmHg
Molecular Formula C13H8D7CL2N3 Melting Point N/A
MSDS N/A Flash Point 204.9±31.5 °C

 Use of Penconazole-d7


Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

 Names

Name Penconazole-d7
Synonym More Synonyms

 Penconazole-d7 Biological Activity

Description Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8.  

[3]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 201736(8):854-866.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 415.3±55.0 °C at 760 mmHg
Molecular Formula C13H8D7CL2N3
Molecular Weight 291.23
Flash Point 204.9±31.5 °C
Exact Mass 290.108246
LogP 3.66
Appearance of Characters White to off-white solid
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.602
Storage condition -20°C
Water Solubility Methanol: slightly soluble

 Synonyms

(±)-Penconazole-d7
CGA 71818-d7
Ofir-d7
Omnex-d7
Topas-d7