2417674-27-0
2417674-27-0 structure
- Name: AMPK-IN-3
- Chemical Name: AMPK-IN-3
- CAS Number: 2417674-27-0
- Molecular Formula: C25H33N5O3
- Molecular Weight: 451.56
- Catalog: Signaling Pathways Epigenetics AMPK
- Create Date: 2022-10-10 19:42:14
- Modify Date: 2023-02-02 12:07:33
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AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1].
| Name | AMPK-IN-3 |
|---|
| Description | AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1]. |
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| Related Catalog | |
| Target |
AMPK (α2):60.7 nM (IC50) AMPK (α1):107 nM (IC50) KDR:3820 nM (IC50) |
| In Vitro | AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively[1]. AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 µM; 2 h) decreases the level of p-ACC in K562 cells[1]. AMPK-IN-3 (1-100 µM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability[1]. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 0.195313, 0.78125, 3.125, 12.5, 50 µM Incubation Time: 2 h Result: Decreased cellular levels of p-ACC(Ser79) in K562 cells. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 1-100 µM Incubation Time: 24, 48, 72 h Result: Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours. |
| References |
| Molecular Formula | C25H33N5O3 |
|---|---|
| Molecular Weight | 451.56 |