2773408-33-4

2773408-33-4 structure

2773408-33-4 structure

Name: Antimalarial agent 16
Chemical Name: Antimalarial agent 16
CAS Number: 2773408-33-4
Molecular Formula: C₃₀H₃₂N₂O₆
Molecular Weight: 516.58
Catalog: Research Areas Infection
Create Date: 2022-10-23 17:48:41
Modify Date: 2024-04-06 11:36:27
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].

Name	Antimalarial agent 16

Description	Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 2.0 nM (P. falciparum)[1]
In Vivo	Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1]. Animal Model: Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1] Dosage: 40 or 200 mg/kg Administration: Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days Result: Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8. Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.
References	[1]. Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:116830.

Molecular Formula	C₃₀H₃₂N₂O₆
Molecular Weight	516.58