2773408-33-4
2773408-33-4 structure
- Name: Antimalarial agent 16
- Chemical Name: Antimalarial agent 16
- CAS Number: 2773408-33-4
- Molecular Formula: C30H32N2O6
- Molecular Weight: 516.58
- Catalog: Research Areas Infection
- Create Date: 2022-10-23 17:48:41
- Modify Date: 2024-04-06 11:36:27
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Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].
| Name | Antimalarial agent 16 |
|---|
| Description | Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1]. |
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| Related Catalog | |
| Target |
IC50: 2.0 nM (P. falciparum)[1] |
| In Vivo | Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1]. Animal Model: Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1] Dosage: 40 or 200 mg/kg Administration: Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days Result: Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8. Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg. |
| References |
| Molecular Formula | C30H32N2O6 |
|---|---|
| Molecular Weight | 516.58 |