2764818-29-1
2764818-29-1 structure
- Name: Antitubercular agent-31
- Chemical Name: Antitubercular agent-31
- CAS Number: 2764818-29-1
- Molecular Formula: C20H24F2N4O5S2
- Molecular Weight: 502.56
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-10-11 18:38:11
- Modify Date: 2024-01-23 23:42:37
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Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1].
| Name | Antitubercular agent-31 |
|---|
| Description | Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 1.1 μM (DprE1)[1] |
| In Vitro | Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%[1]. Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes[1]. |
| In Vivo | Antitubercular agent-31 (10 or 2 mg/kg; p.o. or i.v.; once) displays an acceptable pharmacokinetics (PK) profile with only dosing i.v., shows either poor membrane permeability or rapid clearance rate in vivo[1]. Animal Model: Male Balb/c mice[1] Dosage: 10 mg/kg or 2 mg/kg Administration: Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis) Result: PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg[1]. Tmax (h) Cmax (ng/mL) AUC0-t (h*ng/mL) AUC0-∞ (h*ng/mL) T1/2 (h) CL/F (mL/h/kg) MRT0-∞ (h) 0.1±0.0 463.4±103.4 158.2±18.8 161.3±18.6 0.3±0.0 12515.5±1379.7 0.4±0.0 No compound signal was detected at oral administration. |
| References |
| Molecular Formula | C20H24F2N4O5S2 |
|---|---|
| Molecular Weight | 502.56 |