2764818-29-1

2764818-29-1 structure

Name: Antitubercular agent-31
Chemical Name: Antitubercular agent-31
CAS Number: 2764818-29-1
Molecular Formula: C₂₀H₂₄F₂N₄O₅S₂
Molecular Weight: 502.56
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-11 18:38:11
Modify Date: 2024-01-23 23:42:37
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1].

Name	Antitubercular agent-31

Description	Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 1.1 μM (DprE1)[1]
In Vitro	Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%[1]. Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes[1].
In Vivo	Antitubercular agent-31 (10 or 2 mg/kg; p.o. or i.v.; once) displays an acceptable pharmacokinetics (PK) profile with only dosing i.v., shows either poor membrane permeability or rapid clearance rate in vivo[1]. Animal Model: Male Balb/c mice[1] Dosage: 10 mg/kg or 2 mg/kg Administration: Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis) Result: PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg[1]. Tmax (h) Cmax (ng/mL) AUC0-t (hng/mL) AUC0-∞ (hng/mL) T1/2 (h) CL/F (mL/h/kg) MRT0-∞ (h) 0.1±0.0 463.4±103.4 158.2±18.8 161.3±18.6 0.3±0.0 12515.5±1379.7 0.4±0.0 No compound signal was detected at oral administration.
References	[1]. Shi R, et al. Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents. ACS Med Chem Lett. 2022 Mar 10;13(4):593-598.

Molecular Formula	C₂₀H₂₄F₂N₄O₅S₂
Molecular Weight	502.56