2498762-42-6
2498762-42-6 structure
- Name: Antitubercular agent-32
- Chemical Name: Antitubercular agent-32
- CAS Number: 2498762-42-6
- Molecular Formula: C22H28N4O5S2
- Molecular Weight: 492.61
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-10-15 16:19:15
- Modify Date: 2024-02-18 12:04:31
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Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM)[1].
| Name | Antitubercular agent-32 |
|---|
| Description | Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM)[1]. |
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| Related Catalog | |
| In Vitro | Antitubercular agent-32 (compound 8) (0-7.5 mg/mL; 48 h) shows low cytotoxicity and inhibits M. tuberculosis H37Rv with the minimum inhibition concentration (MIC) of 40 nM[1]. Antitubercular agent-32 (0-20 μM) inhibits decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, 0.5 μM), an enzyme essential for the biosynthesis of mycobacterial cell wall, with an IC50 value of 3.9 μM[1]. Antitubercular agent-32 (1 μM; 10 min) exhibits metabolic stability in the liver microsomal metabolic of both human (HLM) and mouse (MLM), with fast clearance rates of 77 mL/min/kg (HLM) and 163 mL/min/kg (MLM), respectively[1]. Cell Cytotoxicity Assay[1] Cell Line: HepG2 cells Concentration: 0, 15, 30, 75, 150, 300, 750, 1500, 3000, and 7500 ng/mL Incubation Time: 48 hours Result: There were no significantly growth inhibitions of HepG2 cells. |
| References |
| Molecular Formula | C22H28N4O5S2 |
|---|---|
| Molecular Weight | 492.61 |