2787501-83-9
2787501-83-9 structure
- Name: AZD5462
- Chemical Name: AZD5462
- CAS Number: 2787501-83-9
- Molecular Formula: C30H41FN2O6
- Molecular Weight: 544.65
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2022-11-21 11:45:50
- Modify Date: 2024-07-20 19:18:06
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AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties[1].
| Name | AZD5462 |
|---|
| Description | AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties[1]. |
|---|---|
| Related Catalog | |
| Target |
RXFP1[1] |
| In Vitro | AZD5462 (example 1) shows stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively[1]. AZD5462 binds human plasma protein with fraction unbound (free) rate of 4.3%, and shows the stability with Clint values of 23 μL/min/mg (human licer microsomal), 4.8 μL/min/106 cells (human hepatocyte), and 11 μL/min/106 cells (rat hepatocyte)[1]. AZD5462 enhances phosphorylation of ERK with an EC50 value of 6.3 nM[1]. |
| References |
| Molecular Formula | C30H41FN2O6 |
|---|---|
| Molecular Weight | 544.65 |