2700896-78-0

2700896-78-0 structure

Name: BChE-IN-14
Chemical Name: BChE-IN-14
CAS Number: 2700896-78-0
Molecular Formula: C₂₄H₂₉N
Molecular Weight: 331.49
Catalog: Research Areas Neurological Disease
Create Date: 2022-11-06 19:06:51
Modify Date: 2024-01-02 16:39:55
BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease[1].

Name	BChE-IN-14

Description	BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 0.23 μM (eqBChE), 0.011 μM (hBChE)[1]
In Vitro	BChE-IN-14 (0.0001-100 μM) inhibits eqBChE from house serum and hBChE with IC50s of 0.23 and 0.011 μM, respectively[1].
In Vivo	BChE-IN-14 (15 mg/kg; p.o. for Aβ1-42 injection days 3-8) affects memory and cognitive function in AD mice model[1]. Animal Model: ICR mice with oligomerized Aβ1-42 peptide injection[1] Dosage: 15 mg/kg Administration: Oral gavage; 15 mg/kg for Aβ1-42 injection days 3-8 Result: Improved memory and cognitive function in vivo and showed a shorter latency than donepezil.
References	[1]. Lu X, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729.

Molecular Formula	C₂₄H₂₉N
Molecular Weight	331.49