2477737-80-5

2477737-80-5 structure

2477737-80-5 structure

Name: BI 456906
Chemical Name: BI 456906
CAS Number: 2477737-80-5
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Metabolic Disease
Create Date: 2022-10-15 07:09:14
Modify Date: 2024-01-11 08:06:57
BI 456906 is a dual-acting agonist of glucagon-like peptide 1 (GLP-1) receptor and glucagon receptor. BI 456906 can be used for the research of obesity and non-alcoholic steatohepatitis (NASH)[1][2].

Name	BI 456906

Description	BI 456906 is a dual-acting agonist of glucagon-like peptide 1 (GLP-1) receptor and glucagon receptor. BI 456906 can be used for the research of obesity and non-alcoholic steatohepatitis (NASH)[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	BI 456906 potentiates glucose-stimulated insulin secretion from rodent and perifused human islets and potently inhibits glycogen synthesis[2].
In Vivo	BI 456906 reduces food intake, gastric emptying, and improvements in oral glucose tolerance in dose-dependent in single administration to lean mice[2]. BI 456906 led to bodyweight-lowing in DIO mice[2].
References	[1]. John J Nestor, et al. Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis. Sci Rep. 2022 Apr 23;12(1):6666. [2]. R. Augustin, et al. Bi 456906, structural properties and pharmacology of the novel glucagon and glucagon-like peptide-1 receptor (GCGR/GLP-1R) dual agonist. Session E - SO 41 Incretins: basic science.

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