2445205-24-1

2445205-24-1 structure

Name: CDK4/6-IN-12
Chemical Name: CDK4/6-IN-12
CAS Number: 2445205-24-1
Molecular Formula: C₁₂H₁₀N₆
Molecular Weight: 238.25
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-10-12 10:44:14
Modify Date: 2024-01-18 18:32:03
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1].

Name	CDK4/6-IN-12

Description	CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:592.3 nM (IC50) CDK6:3090 nM (IC50)
In Vitro	CDK4/6-IN-12 (compound 4a) inhibits CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively[1].
References	[1]. Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.

Molecular Formula	C₁₂H₁₀N₆
Molecular Weight	238.25