2719679-31-7
2719679-31-7 structure
- Name: MMT5-14
- Chemical Name: MMT5-14
- CAS Number: 2719679-31-7
- Molecular Formula: C39H55N6O8P
- Molecular Weight: 766.86
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2022-10-19 14:16:28
- Modify Date: 2025-08-25 10:58:07
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MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19[1].
| Name | MMT5-14 |
|---|
| Description | MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19[1]. |
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| Related Catalog | |
| In Vitro | MMT5-14 (10 μM; 0-12 h) increases epithelial cell uptake[1]. MMT5-14 (5 μM; 2 d) shows a better in vitro antiviral activity than remdesivir[1]. Cell Viability Assay[1] Cell Line: Vero-E6 cell line Concentration: 5 μM Incubation Time: 2 days Result: Inhibited SARS-CoV-2, alpha, beta, gamma and delta variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. |
| In Vivo | MMT5-14 (10 mg/kg; i.v. once) shows a higher stability than remdesivir in microsomes, and shows higher concentrations of prodrugs and active metabolites (NTP) in blood and lungs[1]. Animal Model: Catheterized female hamsters[1] Dosage: 10 mg/kg Administration: Intravenous injection; 10 mg/kg once Result: Showed higher intact prodrugs concentration than remdesivir in lungs after 4 hours injection, increased tissue exposure in most of the tissues and showed 5- to 10-fold higher tissue selectivity in lungs compared to remdesivir. |
| References |
| Molecular Formula | C39H55N6O8P |
|---|---|
| Molecular Weight | 766.86 |