2272904-53-5
2272904-53-5 structure
- Name: NDI-034858
- Chemical Name: NDI-034858
- CAS Number: 2272904-53-5
- Molecular Formula: C23H24N8O3
- Molecular Weight: 460.49
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2022-11-14 00:45:35
- Modify Date: 2025-08-25 19:46:35
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NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].
| Name | NDI-034858 |
|---|
| Description | NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1]. |
|---|---|
| Related Catalog | |
| Target |
Tyk2 JH2 domain[1] |
| In Vitro | NDI-034858 (compound I-908) (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1]. NDI-034858 inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1]. |
| References |
| Molecular Formula | C23H24N8O3 |
|---|---|
| Molecular Weight | 460.49 |