2272904-53-5

2272904-53-5 structure

2272904-53-5 structure

Name: NDI-034858
Chemical Name: NDI-034858
CAS Number: 2272904-53-5
Molecular Formula: C₂₃H₂₄N₈O₃
Molecular Weight: 460.49
Catalog: Research Areas Inflammation/Immunology
Create Date: 2022-11-14 00:45:35
Modify Date: 2024-01-04 18:04:44
NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].

Name	NDI-034858

Description	NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	Tyk2 JH2 domain[1]
In Vitro	NDI-034858 (compound I-908) (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1]. NDI-034858 inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1].
References	[1]. Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.

Molecular Formula	C₂₃H₂₄N₈O₃
Molecular Weight	460.49