543734-50-5

543734-50-5 structure

Name: NHE3-IN-3
Chemical Name: NHE3-IN-3
CAS Number: 543734-50-5
Molecular Formula: C₁₆H₁₆Cl₂N₂O₂S
Molecular Weight: 371.28
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2022-10-20 21:44:28
Modify Date: 2024-04-06 07:24:59
NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].

Name	NHE3-IN-3

Description	NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease
Target	pIC50: 6.6 (rat NHE3), 6.2 (human NHE3)[1]
References	[1]. Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051.

Molecular Formula	C₁₆H₁₆Cl₂N₂O₂S
Molecular Weight	371.28