Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: NS-8
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

186033-14-7

186033-14-7 structure
186033-14-7 structure
  • Name: NS-8
  • Chemical Name: NS-8
  • CAS Number: 186033-14-7
  • Molecular Formula: C12H10FN3
  • Molecular Weight: 215.23
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
  • Create Date: 2022-10-16 09:44:04
  • Modify Date: 2024-04-05 19:21:06
  • NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

Name NS-8
Description NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].
Related Catalog
In Vivo NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1]. Animal Model: Rats[1] Dosage: 1, 3 and 10 mg/kg Administration: Intraduodenal administration, intravenous injection Result: Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure). Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude. Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
References

[1]. M Tanaka, et al. A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. 2003 Dec;92(9):1031-6.

Molecular Formula C12H10FN3
Molecular Weight 215.23