2366152-15-8
2366152-15-8 structure
- Name: RPT193
- Chemical Name: RPT193
- CAS Number: 2366152-15-8
- Molecular Formula: C27H34Cl3N5O2
- Molecular Weight: 566.95
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2022-10-29 18:13:19
- Modify Date: 2024-04-05 17:32:15
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RPT193 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. RPT193 can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research[1].
| Name | RPT193 |
|---|
| Description | RPT193 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. RPT193 can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research[1]. |
|---|---|
| Related Catalog | |
| Target |
CCR4 |
| In Vitro | RPT193 (1 nM-10 μM) inhibits Th2 cells chemotaxis or migration with IC50s of ~370 nM[2]. |
| In Vivo | RPT193 (100 mg/kg; p.o.; once daily; 2 d, 1 d before OVA-challenge) reduces skin inflammation in an acute ovalbumin (OVA)-induced atopic dermatitis model in mice[2]. Animal Model: Acute ovalbumin (OVA)-induced atopic dermatitis model in mouse[2] Dosage: 100 mg/kg Administration: Oral gavage; once daily; for 2 days, started 1 day before OVA-challenge (in mouse ear) Result: Decreased the ear thickness significantly. |
| References |
| Molecular Formula | C27H34Cl3N5O2 |
|---|---|
| Molecular Weight | 566.95 |