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92575-00-3

92575-00-3 structure

92575-00-3 structure

Name: Tubulin inhibitor 12
Chemical Name: Tubulin inhibitor 12
CAS Number: 92575-00-3
Molecular Formula: C₂₄H₂₀N₂O
Molecular Weight: 352.43
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2022-11-21 19:53:58
Modify Date: 2024-01-16 18:21:32
Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC50=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity[1].

Name	Tubulin inhibitor 12

Description	Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC50=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Tubulin inhibitor 12 (0-100 μM; 72 h) shows moderate and broad-spectrum anti-proliferative activity[1]. Cell Proliferation Assay[1] Cell Line: HepG2, A549, and HCT116 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed IC50 values of 49.13, 52.84, and 70.10 μM for HepG2, A549, and HCT116 cells, respectively.
References	[1]. Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.

Molecular Formula	C₂₄H₂₀N₂O
Molecular Weight	352.43

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