148333-42-0

148333-42-0 structure

Name: Ac-Leu-Leu-Norleucinol
Chemical Name: Ac-Leu-Leu-Norleucinol
CAS Number: 148333-42-0
Molecular Formula: C₂₀H₃₇N₃O₅
Molecular Weight: 399.52
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2022-11-18 16:57:17
Modify Date: 2024-09-10 13:06:09
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].

Name	Ac-Leu-Leu-Norleucinol

Description	Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Target	Calpain[1]
In Vivo	Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1]. Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1] Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.) Administration: Intraperitoneal injection; collected tissue samples 24 hr after Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). Injection alone did not cause pathological changes in the liver.
References	[1]. Song Fuyong, et al. Application of calpain inhibitor ALLN in preventing and treating acetaminophen induced acute liver damage: China, CN108939046[P]. 2018-12-07.

Molecular Formula	C₂₀H₃₇N₃O₅
Molecular Weight	399.52