1458656-71-7

1458656-71-7 structure

Name: BI-2081
Chemical Name: BI-2081
CAS Number: 1458656-71-7
Molecular Formula: C₃₂H₃₅FO₆
Molecular Weight: 534.62
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2022-11-15 12:20:57
Modify Date: 2025-10-05 19:22:06
BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2[1].

Name	BI-2081

Description	BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
Target	GPR40 (FFAR1)[1]
References	[1]. Governa P, et al. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity. Bioorg Med Chem Lett. 2021 Jun 1;41:127969.

Molecular Formula	C₃₂H₃₅FO₆
Molecular Weight	534.62