2490709-68-5

2490709-68-5 structure

2490709-68-5 structure

Name: DKFZ-748
Chemical Name: DKFZ-748
CAS Number: 2490709-68-5
Molecular Formula: C₁₈H₂₃N₃O₃
Molecular Weight: 329.39
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-11-12 13:30:54
Modify Date: 2023-01-23 20:40:06
DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].

Name	DKFZ-748

Description	DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model[1]. DKFZ-748 (1-100 μM; 72 h) induces acetylation of BE(2)-C cells[1]. DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: BE(2)-C cells Concentration: 1, 10, 100 μM Incubation Time: 72 h Result: Induced significant acetylation only at the highest tested concentration (100 μM).
References	[1]. Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875.

Molecular Formula	C₁₈H₂₃N₃O₃
Molecular Weight	329.39