2490709-68-5
2490709-68-5 structure
- Name: DKFZ-748
- Chemical Name: DKFZ-748
- CAS Number: 2490709-68-5
- Molecular Formula: C18H23N3O3
- Molecular Weight: 329.39
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-11-12 13:30:54
- Modify Date: 2024-09-16 10:12:50
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DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].
| Name | DKFZ-748 |
|---|
| Description | DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model[1]. DKFZ-748 (1-100 μM; 72 h) induces acetylation of BE(2)-C cells[1]. DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: BE(2)-C cells Concentration: 1, 10, 100 μM Incubation Time: 72 h Result: Induced significant acetylation only at the highest tested concentration (100 μM). |
| References |
| Molecular Formula | C18H23N3O3 |
|---|---|
| Molecular Weight | 329.39 |