2260887-57-6

2260887-57-6 structure
2260887-57-6 structure
  • Name: TH-Z145
  • Chemical Name: TH-Z145
  • CAS Number: 2260887-57-6
  • Molecular Formula: C16H28O7P2
  • Molecular Weight: 394.34
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2022-11-21 13:56:01
  • Modify Date: 2024-04-08 20:08:43
  • TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1].

Name TH-Z145
Description TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1].
Related Catalog
Target

FPPS[1]

In Vivo TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1]. Animal Model: B16-OVA cells (s.c.) xenograft mice model[1]. Dosage: 20 μg Administration: Intraperitoneal injection (i.p.) Result: Inhibited tumor growth and prolonged survival.
References

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.

Molecular Formula C16H28O7P2
Molecular Weight 394.34
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