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370096-57-4

370096-57-4 structure

370096-57-4 structure

Name: ROS kinases-IN-1
Chemical Name: WAY-602746
CAS Number: 370096-57-4
Molecular Formula: C₂₀H₁₆N₄O
Molecular Weight: 328.373
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ROS
Create Date: 2022-12-14 08:35:23
Modify Date: 2024-04-04 00:01:01
ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity[1].

Name	WAY-602746

Description	ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Target	IC50: 1.22 μM (ROS kinase)[1]
In Vitro	ROS kinases-IN-1 (1-100 μM; 1 d) inhibits the growth of cervical cancer cell and glioblastoma cells[1]. Cell Viability Assay[1] Cell Line: HeLa, U138, U87, LN18, and U118 cells Concentration: 1, 10, and 100 μM Incubation Time: one day Result: Showed EC50s for HeLa, U138, U87, LN18, and U118 cells of 20, 8, 8, 12, and 7 μM, respectively.
References	[1]. Dorre A. GRUENEBERG, et al. Novel methods, compounds, and compositions for inhibition of ros. WO2014141129A2.

Molecular Formula	C₂₀H₁₆N₄O
Molecular Weight	328.373

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