Shanghai Nianxing Industrial Co., Ltd
China
Product Name: smilagenin
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Purity: 98.0%
Stocking Period: 10 Day
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126-18-1

126-18-1 structure

Name: smilagenin
Chemical Name: (25R)-5β-spirostan-3β-ol
CAS Number: 126-18-1
Molecular Formula: C₂₇H₄₄O₃
Molecular Weight: 416.63600
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-04-02 08:00:00
Modify Date: 2024-01-02 17:24:43
Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2].Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].

Name	(25R)-5β-spirostan-3β-ol
Synonyms	(25R)-5beta-spirostan-3beta-ol ISOSARSAPOGENIN (25R)-SPIROSTAN-3BETA-OL SMILAGENIN EINECS 204-775-8 (25R)-Spirostan-3.β.-ol ESMILAGENIN ISOSARSAPOGENINE ISOSARSASAPOGENIN MFCD00037845 25R,5BETA-SPIROSTAN-3BETA-OL

Description	Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2].Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3]. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2]. Cell Viability Assay[3] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Elevated the SH-SY5Y cell viability. RT-PCR[2] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased GDNF and BDNF transcription.
In Vivo	Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2]. Animal Model: MPTP/probenecid-induced mouse model[2] Dosage: 10 or 26 mg/kg Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.
References	[1]. He X, et al. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Front Cell Neurosci. 2019 Feb 5;13:18. [2]. Hu Y, et al. Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiol Aging. 2010 Jun;31(6):1010-9. [3]. Zhang R, et al. Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May 17;210:275-85

Density	1.11g/cm3
Boiling Point	516.6ºC at 760mmHg
Melting Point	-185ºC
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.63600
Flash Point	266.2ºC
Exact Mass	416.32900
PSA	38.69000
LogP	5.79380
Vapour Pressure	7.83E-13mmHg at 25°C
Index of Refraction	1.552
Storage condition	2-8℃

WGK Germany	3

126-18-1	82597-74-8
4947-75-5	4948-43-0