547698-18-0
547698-18-0 structure
- Name: Necroptosis-IN-3
- Chemical Name: WAY-620847
- CAS Number: 547698-18-0
- Molecular Formula: C12H17NOS
- Molecular Weight: 223.34
- Catalog: Research Areas Cancer
- Create Date: 2022-12-01 11:03:20
- Modify Date: 2024-01-12 09:45:12
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Necroptosis-IN-3 (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].
| Name | WAY-620847 |
|---|---|
| Synonyms |
N-(2-Thienylmethyl)cyclohexanecarboxamide
Cyclohexanecarboxamide, N-(2-thienylmethyl)- MFCD03397171 |
| Description | Necroptosis-IN-3 (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2]. |
|---|---|
| Related Catalog | |
| Target |
Necroptosis[1], 11β-HSD1[2] |
| In Vitro | TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) 抑制 TNF-α 诱导的 FADD 缺陷人 Jurkat T 细胞坏死[1]。 Cell Viability Assay[1] Cell Line: Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α Concentration: 0.030-100 μM Incubation Time: 24 h Result: Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells. |
| References |
[1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 422.4±24.0 °C at 760 mmHg |
| Molecular Formula | C12H17NOS |
| Molecular Weight | 223.34 |
| Flash Point | 209.3±22.9 °C |
| Exact Mass | 223.103088 |
| LogP | 2.48 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.557 |