547698-18-0

547698-18-0 structure

Name: Necroptosis-IN-3
Chemical Name: WAY-620847
CAS Number: 547698-18-0
Molecular Formula: C₁₂H₁₇NOS
Molecular Weight: 223.34
Catalog: Research Areas Cancer
Create Date: 2022-12-01 11:03:20
Modify Date: 2024-01-12 09:45:12
Necroptosis-IN-3 (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].

Name	WAY-620847
Synonyms	N-(2-Thienylmethyl)cyclohexanecarboxamide Cyclohexanecarboxamide, N-(2-thienylmethyl)- MFCD03397171

Description	Necroptosis-IN-3 (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	Necroptosis[1], 11β-HSD1[2]
In Vitro	TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) 抑制 TNF-α 诱导的 FADD 缺陷人 Jurkat T 细胞坏死[1]。 Cell Viability Assay[1] Cell Line: Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α Concentration: 0.030-100 μM Incubation Time: 24 h Result: Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells.
References	[1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1. [2]. Nigel Vicker, et al. Compound. Patent US20100120789A1.