2758520-84-0
2758520-84-0 structure
- Name: Antitumor agent-80
- Chemical Name: Antitumor agent-80
- CAS Number: 2758520-84-0
- Molecular Formula: C24H20ClNO2
- Molecular Weight: 389.87
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-12-12 20:37:09
- Modify Date: 2024-04-08 16:29:15
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Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells[1].
| Name | Antitumor agent-80 |
|---|
| Description | Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells[1]. |
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| Related Catalog | |
| In Vitro | Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells[1]. Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines[1]. Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel[1]. hepatocellular carcinoma IC50 (μM) breast IC50 (μM) Huh7 1.3 MCF7 3.8 HepG2 2.1 MDA-MB231 2.0 SNU475 1.7 MDA-MB468 2.8 Hep3B 3.0 SKBR3 3.5 FOCUS 2.1 ZR75 7.6 Hep40 8.6 MCF10A 12.1 PLC-PRF-5 9.5 Mahlavu 3.2 Western Blot Analysis[1] Cell Line: Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells Concentration: 5 μM Incubation Time: 48 h Result: Caused the increase in PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu). Cell Proliferation Assay[1] Cell Line: Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells Concentration: 10 μM, 5 μM, 2.5 μM Incubation Time: 96 h Result: Caused inhibition in the growth of both breast and hepatocellular carcinoma cell lines. |
| In Vivo | Antitumor agent-80 (compound 11) (40 mg/kg, Orally, twice a week, for 4 weeks) displays antitumor activity in vivo in the Mahlavu hepatocellular carcinoma and the MDA-MB-231 breast cancer xenograft models[1]. Animal Model: Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)[1] Dosage: 40 mg/kg Administration: Orally, twice a week, for 4 weeks Result: In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group. |
| Molecular Formula | C24H20ClNO2 |
|---|---|
| Molecular Weight | 389.87 |