Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CBP/p300-IN-10
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Purity: 98.0%
Stocking Period: 10 Day
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2259641-71-7

2259641-71-7 structure

2259641-71-7 structure

Name: CBP/p300-IN-10
Chemical Name: CBP/p300-IN-10
CAS Number: 2259641-71-7
Molecular Formula: C₂₅H₂₄F₅N₅O₃
Molecular Weight: 537.48
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2022-11-22 08:42:45
Modify Date: 2024-04-08 19:44:32
CBP/p300-IN-10 is a highly potent histone acetyltransferase EP300 and CREBBP with IC50 values of 26 nM and 39 nM, respectively. CBP/p300-IN-10 can be used to research anticancer[1].

Name	CBP/p300-IN-10

Description	CBP/p300-IN-10 is a highly potent histone acetyltransferase EP300 and CREBBP with IC50 values of 26 nM and 39 nM, respectively. CBP/p300-IN-10 can be used to research anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	EP300:26 nM (IC50) CREBBP:39 nM (IC50)
In Vitro	CBP/p300-IN-10 (example 84) (0-1 μM; 3 h) inhibit H3K27Ac activity in LK2 cells with an IC50 of 22 nM[1]. CBP/p300-IN-10 (38 nM-10 mM; 3 days) has inhibitory activity against LK2 and TE-8[1]. Cell Proliferation Assay[1] Cell Line: LK2 and TE-8 Concentration: 38 nM-10 mM Incubation Time: 3 days Result: Inhibited LK2 and TE-8 with GI50s of 97.163 nM and 152.484 nM, respectively.
References	[1]. Naito, Hiroyuki, et al. Preparation of amino acid amide derivatives such as L- and D-prolinamide derivatives as Ep300/CREBBP inhibitors. WO2018235966A1

Molecular Formula	C₂₅H₂₄F₅N₅O₃
Molecular Weight	537.48

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