2414896-32-3
2414896-32-3 structure
- Name: CDK7-IN-11
- Chemical Name: CDK7-IN-11
- CAS Number: 2414896-32-3
- Molecular Formula: C26H28N6O2S
- Molecular Weight: 488.60
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-12-16 18:07:44
- Modify Date: 2024-04-05 22:09:25
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CDK7-IN-11 is an orally active CDK7 inhibitor. CDK7-IN-11 exhibits high CDK7 inhibitory activity with IC50 value of 4.2 nM. CDK7-IN-11 can be effectively used for the research of diseases associated with CDK7[1].
| Name | CDK7-IN-11 |
|---|
| Description | CDK7-IN-11 is an orally active CDK7 inhibitor. CDK7-IN-11 exhibits high CDK7 inhibitory activity with IC50 value of 4.2 nM. CDK7-IN-11 can be effectively used for the research of diseases associated with CDK7[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK7:4.2 nM (IC50) |
| In Vitro | CDK7-IN-11 (example 5) has inhibitory activity for CDK7 with IC50 value of 4.2 nM[1]. CDK7-IN-11 (72 h) inhibits cell proliferation in MDA-MB-468 cells and HepG2 cells with IC50 values of 14.0 nM and 3.0 nM[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-468 cells, HepG2 cells Concentration: Incubation Time: 72 h Result: Showed antiproliferative effect in cells. |
| References |
[1]. Novel cdk7 inhibitory compound or pharmaceutically acceptable salt thereof. Patent. WO2021182914A1. |
| Molecular Formula | C26H28N6O2S |
|---|---|
| Molecular Weight | 488.60 |