2648221-12-7

2648221-12-7 structure

Name: KRAS G12D inhibitor 16
Chemical Name: KRAS G12D inhibitor 16
CAS Number: 2648221-12-7
Molecular Formula: C₃₂H₃₉IN₆O₃
Molecular Weight: 682.59
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2022-11-27 11:15:36
Modify Date: 2024-04-07 00:03:50
KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].

Name	KRAS G12D inhibitor 16

Description	KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12D:0.7 nM (IC50)
In Vitro	KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1]. KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].
References	[1]. Yuichi Kawai, et al. A compound having inhibitory activity against kras g12d mutation. Patent. WO2021107160A1.

Molecular Formula	C₃₂H₃₉IN₆O₃
Molecular Weight	682.59