1915012-21-3
1915012-21-3 structure
- Name: PBRM1-BD2-IN-1
- Chemical Name: PBRM1-BD2-IN-1
- CAS Number: 1915012-21-3
- Molecular Formula: C17H19ClN2O
- Molecular Weight: 302.80
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-11-27 10:48:04
- Modify Date: 2024-04-05 20:54:09
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PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer[1].
| Name | PBRM1-BD2-IN-1 |
|---|
| Description | PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
Kd: 0.7 μM (PBRM1-BD2), 0.35 μM (PBRM1-BD5), 8.1 μM (SMARCA2B), 5.0 μM (SMARCA4) [1]. IC50: 0.2 μM (PBRM1-BD2)[1]. |
| In Vitro | PBRM1-BD2-IN-1 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1]. PBRM1-BD2-IN-1 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 0.7 μM, 0.35 μM, 8.1 μM and 5.0 μM, respectively[1]. PBRM1-BD2-IN-1 has inhibitory activity for PBRM1-BD2 with IC50 value of 0.2 μM[1]. Cell Viability Assay[1] Cell Line: Human prostate cell lines LNCaP, PC3, and RWPE-1 Concentration: 0, 0.1, 1, and 10 μM Incubation Time: 5 days Result: Inhibited LNCaP growth at higher concentrations. |
| Molecular Formula | C17H19ClN2O |
|---|---|
| Molecular Weight | 302.80 |