2819989-57-4
2819989-57-4 structure
- Name: PBRM1-BD2-IN-2
- Chemical Name: PBRM1-BD2-IN-2
- CAS Number: 2819989-57-4
- Molecular Formula: C14H9Cl2FN2O
- Molecular Weight: 311.14
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-11-27 16:13:46
- Modify Date: 2024-02-27 12:08:48
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PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer[1].
| Name | PBRM1-BD2-IN-2 |
|---|
| Description | PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
Kd: 9.3 μM (PBRM1-BD2), 10.1 μM (PBRM1-BD5), 18.4 μM (SMARCA2B), 69 μM (SMARCA4)[1]. IC50: 1.0 μM (PBRM1-BD2)[1]. |
| In Vitro | PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1]. PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively[1]. PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM[1]. Cell Viability Assay[1] Cell Line: Human prostate cell lines LNCaP, PC3, and RWPE-1 Concentration: 0, 0.1, 1, and 10 μM Incubation Time: 5 days Result: Inhibited LNCaP growth at higher concentrations. |
| Molecular Formula | C14H9Cl2FN2O |
|---|---|
| Molecular Weight | 311.14 |