2834739-51-2
2834739-51-2 structure
- Name: TH470
- Chemical Name: TH470
- CAS Number: 2834739-51-2
- Molecular Formula: C30H31N5O5S2
- Molecular Weight: 605.73
- Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
- Create Date: 2022-11-21 18:25:01
- Modify Date: 2024-04-08 17:22:59
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TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1].
| Name | TH470 |
|---|
| Description | TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1]. |
|---|---|
| Related Catalog | |
| Target |
LIMK1:9.8 nM (IC50) LIMK2:13 nM (IC50) |
| In Vitro | TH470 (0.05-5 μM; 12 h) inhibits the growth of neurite[1]. Cell Viability Assay[1] Cell Line: N1E-115 cells transfected with siRNAs against FMR1 (siFMR1) or control siRNAs (siCtr) Concentration: 0.05, 0.5, or 5 μM Incubation Time: 12 hours Result: Inhibited neurite outgrowth in a dose-dependent manner. |
| Molecular Formula | C30H31N5O5S2 |
|---|---|
| Molecular Weight | 605.73 |