TH470
Modify Date: 2025-09-02 17:59:30
TH470 structure
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Common Name | TH470 | ||
|---|---|---|---|---|
| CAS Number | 2834739-51-2 | Molecular Weight | 605.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31N5O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH470TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1]. |
| Name | TH470 |
|---|
| Description | TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1]. |
|---|---|
| Related Catalog | |
| Target |
LIMK1:9.8 nM (IC50) LIMK2:13 nM (IC50) |
| In Vitro | TH470 (0.05-5 μM; 12 h) inhibits the growth of neurite[1]. Cell Viability Assay[1] Cell Line: N1E-115 cells transfected with siRNAs against FMR1 (siFMR1) or control siRNAs (siCtr) Concentration: 0.05, 0.5, or 5 μM Incubation Time: 12 hours Result: Inhibited neurite outgrowth in a dose-dependent manner. |
| Molecular Formula | C30H31N5O5S2 |
|---|---|
| Molecular Weight | 605.73 |
| InChIKey | YVPYJSSYGACUSE-UHFFFAOYSA-N |
| SMILES | CC(C)C(=O)Nc1ncc(C(=O)NCCN(Cc2ccccc2)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3)cc2)s1 |