1327278-94-3

1327278-94-3 structure

Name: Abicipar pegol
Chemical Name: Abicipar pegol
CAS Number: 1327278-94-3
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2023-01-16 13:54:07
Modify Date: 2024-02-19 18:48:44
Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area[1][2].

Name	Abicipar pegol

Description	Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
References	[1]. Gerard A Rodrigues, et al. Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5836-5846. [2]. Sepehr Bahadorani, et al. Recent advances in the management and understanding of macular degeneration. F1000Res. 2017 Apr 20;6:519.

No Any Chemical & Physical Properties