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459844-20-3

459844-20-3 structure

459844-20-3 structure

Name: Arylomycin A2
Chemical Name: Arylomycin A2
CAS Number: 459844-20-3
Molecular Formula: C₄₂H₆₀N₆O₁₁
Molecular Weight: 824.96
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2023-05-06 18:34:01
Modify Date: 2024-01-07 01:03:22
Arylomycin A2, an Antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1].

Name	Arylomycin A2

Description	Arylomycin A2, an Antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Arylomycin A2 exhibits very potent antibacterial activity against free-living S. epidermidis cells. The MIC values against planktonic S. epidermidis 1457 and RP62A are 0.235 μg/mL and 0.058 μg/mL for Arylomycin A2, respectively. Arylomycin A2 shows the antibacterial effect towards S. epidermidis biofilms, and reduces biofilm formation markedly[2].
References	[1]. Mark Paetzel, et al. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. J Biol Chem. 2004 Jul 16;279(29):30781-90. [2]. Katrijn Bockstael, et al. Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis. Microbiology (Reading). 2009 Nov;155(Pt 11):3719-3729.

Molecular Formula	C₄₂H₆₀N₆O₁₁
Molecular Weight	824.96

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