Arylomycin A2

Modify Date: 2024-01-07 01:03:22

Arylomycin A2 structure	Common Name	Arylomycin A2
	CAS Number	459844-20-3	Molecular Weight	824.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₆₀N₆O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Arylomycin A2

Arylomycin A2, an Antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1].

Name	Arylomycin A2

Description	Arylomycin A2, an Antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Arylomycin A2 exhibits very potent antibacterial activity against free-living S. epidermidis cells. The MIC values against planktonic S. epidermidis 1457 and RP62A are 0.235 μg/mL and 0.058 μg/mL for Arylomycin A2, respectively. Arylomycin A2 shows the antibacterial effect towards S. epidermidis biofilms, and reduces biofilm formation markedly[2].
References	[1]. Mark Paetzel, et al. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. J Biol Chem. 2004 Jul 16;279(29):30781-90. [2]. Katrijn Bockstael, et al. Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis. Microbiology (Reading). 2009 Nov;155(Pt 11):3719-3729.

Molecular Formula	C₄₂H₆₀N₆O₁₁
Molecular Weight	824.96