2407356-67-4
2407356-67-4 structure
- Name: CD73-IN-14
- Chemical Name: CD73-IN-14
- CAS Number: 2407356-67-4
- Molecular Formula: C26H26ClN7O9
- Molecular Weight: 615.98
- Catalog: Research Areas Cancer
- Create Date: 2023-01-30 09:51:40
- Modify Date: 2024-04-08 10:32:53
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D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1].
| Name | CD73-IN-14 |
|---|
| Description | D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
C50: 0.17 nM (CD73)[1] |
| In Vivo | CD73-IN-14 (10, 25, 50 mg/kg; p.o.; twice-a-day for 20 days) shows anti-tumor activity in mouse[1].br/>Pharmacokinetic Parameters of CD73-IN-14 in rats[1]. PO Dose (mg/kg) AUC0-24 h (ng*hr/mL) Cmax(nM) Tmax(hr) 50 580 74 0.8 200 6094 1800 0.8 500 18500 11000 0.3 rats, 50, 200, 500 mg/kg p.o.[1] Animal Model: C57BL/6 mice (EG7 model)[1] Dosage: 10, 25, 50 mg/kg Administration: P.o.; twice a day for 20 days Result: Increased tumor-infiltrating CD8+ cells and decreased the tumor volume in a dose dependet manner. |
| References |
| Molecular Formula | C26H26ClN7O9 |
|---|---|
| Molecular Weight | 615.98 |