Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FSHR agonist 1
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1256776-89-2

1256776-89-2 structure

1256776-89-2 structure

Name: FSHR agonist 1
Chemical Name: FSHR agonist 1
CAS Number: 1256776-89-2
Molecular Formula: C₂₆H₃₃N₃O₃S
Molecular Weight: 467.62
Catalog: Research Areas Endocrinology
Create Date: 2023-01-21 07:41:45
Modify Date: 2024-04-06 22:04:47
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1].

Name	FSHR agonist 1

Description	FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
Target	pEC50: 7.72 (FSHR)[1]
In Vitro	FSHR agonist 1 (compound 21f) 与 FSHR TMD 口袋的结合诱导 TM6 和 TM7 向内运动，这直接导致 FSHR 激活[1]。 FSHR agonist 1 (compound 21f) 可以高效激活 FSHR、LHCGR 和 TSHR，而对 FSHR 的激活效力比 LHCGR（pEC50 为 6.26）和 TSHR（pEC50 为 6.48）高 10 倍以上[1]。
References	[1]. Jia Duan, et al. Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor. biorxiv. August 01, 2022.

Molecular Formula	C₂₆H₃₃N₃O₃S
Molecular Weight	467.62