905703-97-1
905703-97-1 structure
- Name: Ganitumab
- Chemical Name: Ganitumab
- CAS Number: 905703-97-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK IGF-1R
- Create Date: 2023-01-14 16:13:43
- Modify Date: 2024-04-05 22:09:33
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Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].
| Name | Ganitumab |
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| Description | Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1]. |
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| Related Catalog | |
| In Vitro | Ganitumab (AMG 479; 0.032-500 nM; 10 分钟; CT26 细胞) 结合 mIGF1R 并抑制 IGF1 和 IGF2 介导的 mIGF1R 的激活[1]。 Western Blot Analysis[1] Cell Line: CT26 cells Concentration: 0.032-500 nM Incubation Time: 10 minutes Result: Inhibited IGF1-induced autophosphorylation of mIGF1R in CT26 murine colon carcinoma cells in a dose-dependent manner. |
| In Vivo | Ganitumab (AMG 479; 1 mg/剂; i.p; Naïve 和荷瘤小鼠) 抑制 IGF1 诱导的小鼠肺中 mIGF1R 的激活[1]。 Ganitumab (300 μg/剂; i.p.; 雌性无胸腺裸鼠) 减少外周血中性粒细胞[1]。 Ganitumab (300 μg/剂; i.p.;雄性无胸腺裸鼠) 导致雄性小鼠糖耐量受损，并增加血清中 mGH，mIGF1 和 mIGFBP3[1]。 Animal Model: Naïve and tumor-bearing mice[1] Dosage: 1 mg/dose Administration: Intraperitoneal injection Result: Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth. Animal Model: Male athymic nude mice[1] Dosage: 300 μg/dose Administration: Intraperitoneal injection, twice per week for a total of five doses Result: Had significantly higher serum glucose levels than hIgG1-pretreated mice. Increased serum levels of mIGF1, mIGFPB3 and mGH. Animal Model: Female athymic nude mice[1] Dosage: 300 μg/dose Administration: Intraperitoneal injection, twice per week for a total of five doses Result: Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls. |
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| No Any Chemical & Physical Properties |