2649776-79-2

2649776-79-2 structure

2649776-79-2 structure

Name: MPH-220
Chemical Name: MPH-220
CAS Number: 2649776-79-2
Molecular Formula: C₂₀H₂₁N₃O₃S
Molecular Weight: 383.46
Catalog: Signaling Pathways Cytoskeleton Myosin
Create Date: 2023-01-11 19:17:13
Modify Date: 2024-01-31 17:39:29
MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

Name	MPH-220

Description	MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Myosin Research Areas >> Neurological Disease
In Vitro	MPH-220 (0-50 µM) 抑制人肌肉肌球蛋白样品中肌动蛋白激活的 ATP 酶活性[1]。
In Vivo	MPH-220 (25-30 mg/kg，腹腔注射或口服灌胃) 可降低麻醉大鼠的骨骼肌力量，而不会影响心血管[1]。 MPH-220 (15 mg/kg，口服) 改善脑损伤大鼠的步态功能[1]。 Animal Model: Anesthetized rats[1] Dosage: 25-30 mg/kg Administration: Intraperitoneal injection (i.p.) or oral gavage Result: Reduced skeletal muscle force. Observed MPH-220 distribution in rat tissues in a time-dependent manner and a dose-dependent, few-fold accumulation in skeletal muscle.
References	[1]. Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.

Molecular Formula	C₂₀H₂₁N₃O₃S
Molecular Weight	383.46