MPH-220

Modify Date: 2024-01-31 17:39:29

MPH-220 Structure
MPH-220 structure
Common Name MPH-220
CAS Number 2649776-79-2 Molecular Weight 383.46
Density N/A Boiling Point N/A
Molecular Formula C20H21N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MPH-220


MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

 Names

Name MPH-220

 MPH-220 Biological Activity

Description MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].
Related Catalog
In Vitro MPH-220 (0-50 µM) 抑制人肌肉肌球蛋白样品中肌动蛋白激活的 ATP 酶活性[1]。
In Vivo MPH-220 (25-30 mg/kg,腹腔注射或口服灌胃) 可降低麻醉大鼠的骨骼肌力量,而不会影响心血管[1]。 MPH-220 (15 mg/kg,口服) 改善脑损伤大鼠的步态功能[1]。 Animal Model: Anesthetized rats[1] Dosage: 25-30 mg/kg Administration: Intraperitoneal injection (i.p.) or oral gavage Result: Reduced skeletal muscle force. Observed MPH-220 distribution in rat tissues in a time-dependent manner and a dose-dependent, few-fold accumulation in skeletal muscle.
References

[1]. Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.  

 Chemical & Physical Properties

Molecular Formula C20H21N3O3S
Molecular Weight 383.46
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