916888-49-8
916888-49-8 structure
- Name: N-Acetyldopamine dimer-2
- Chemical Name: N-Acetyldopamine dimer-2
- CAS Number: 916888-49-8
- Molecular Formula: C20H20N2O6
- Molecular Weight: 384.38
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2023-01-16 17:13:07
- Modify Date: 2025-08-26 07:06:12
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N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity[1].
| Name | N-Acetyldopamine dimer-2 |
|---|
| Description | N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity[1]. |
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| Related Catalog | |
| Target |
IC50: 1.5 μM (copper-mediated LDL oxidation), 2.7 μM (AAPH-mediated LDL oxidation), 1.6 μM (SIN-1-mediated LDL oxidation)[1] |
| In Vitro | N-Acetyldopamine dimer-2 inhibits copper-mediated, 2,2’azobis(2-amidinopropane) hydrochloride (AAPH)-mediated, and 3-morpholinosydnonimine (SIN)-1-mediated LDL oxidation with IC50 values of 1.5, 2.7 and 1.6 μM, respectively[1]. N-Acetyldopamine dimer-2 (100 μM; 40 min) shows strong radical scavenging capacity[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently reduces the ROS level in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently and slightly decreases the NO production and iNOS protein expression in LPS-stimulated RAW264.7 cells[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) decreases the mRNA levels of IL-6, TNF-α, and COX-2 and dose-dependently inhibits secretion of IL-6, and inhibits the LPS-induced NF-κB activation in RAW264.7 cells[1]. Western Blot Analysis[1] Cell Line: LPS-stimulated RAW264.7 cell line Concentration: 200 and 400 μM Incubation Time: 2 hours Result: Slightly decreased iNOS protein expression in LPS-stimulated RAW264.7 cells. Western Blot Analysis[1] Cell Line: LPS-stimulated RAW264.7 cell line Concentration: 200 and 400 μM Incubation Time: 2 hours Result: Dose-dependently decreased the mRNA levels of IL-6, TNF-α and COX-2. |
| References |
| Molecular Formula | C20H20N2O6 |
|---|---|
| Molecular Weight | 384.38 |