2108782-45-0

2108782-45-0 structure

Name: Narsoplimab
Chemical Name: Narsoplimab
CAS Number: 2108782-45-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-01-22 22:54:55
Modify Date: 2024-01-07 12:03:13
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1].

Name	Narsoplimab

Description	Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vitro	Narsoplimab (100 nM; 3 h; Vero E6 细胞和带有 SARS-CoV-2 的 Vero E6 细胞) 抑制了 N 蛋白增强的 MASP-2 沉积[1]。
In Vivo	Narsoplimab (10 mg/kg; i.v.; WT and Masp2-/- (KO) mice) 降低了小鼠淋巴细胞百分比 (Lym%)，增加了中性粒细胞百分比 (Neu%)[1]。 Animal Model: WT and Masp2-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)[1] Dosage: 10 mg/kg Administration: Intravenous injection Result: Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).
References	[1]. Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318.

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