1186098-83-8
1186098-83-8 structure
- Name: Oxelumab
- Chemical Name: Oxelumab
- CAS Number: 1186098-83-8
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2023-01-16 10:26:04
- Modify Date: 2025-07-26 23:10:00
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Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma[1].
| Name | Oxelumab |
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| Description | Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma[1]. |
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| Related Catalog | |
| In Vitro | Oxelumab (10 μg/mL; 3 d) represses cell proliferation of NK cells[2]. Cell Proliferation Assay[2] Cell Line: Natural Killer (NK) cell lines Concentration: 10 μg/mL Incubation Time: 3 days Result: Inhibited cell proliferation of NK cells. |
| In Vivo | Oxelumab (5 and 30 mg/kg; i.p., once daily for twice) affects the concentrations of IL-6 and the frequencies of splenic human effector memory T cells and switched B cells[1]. Animal Model: NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)[1] Dosage: 5 and 30 mg/kg Administration: Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13 Result: Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells. |
| References |
| No Any Chemical & Physical Properties |