1531594-08-7

1531594-08-7 structure

Name: Tesidolumab
Chemical Name: Tesidolumab
CAS Number: 1531594-08-7
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Complement System
Create Date: 2023-01-15 11:04:23
Modify Date: 2024-07-10 13:07:28
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex[1].

Name	Tesidolumab

Description	Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Inflammation/Immunology
In Vitro	Tesidolumab (LFG316) possesses a half-life in humans of approximately 9 days. Tesidolumab (LFG316) binds to a distinct epitope to that of eculizumab and ravulizumab, distant to Arg 885[1].
References	[1]. Jun-Ichi Nishimura, et al. Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria. Haematologica. 2022 Jun 1;107(6):1483-1488.

No Any Chemical & Physical Properties